Combining Cialis (tadalafil) with poppers (alkyl nitrites) poses significant health risks and is strongly discouraged. Both substances are vasodilators, meaning they relax blood vessels and lower blood pressure. When used together, this effect can be dangerously amplified, leading to a sudden and severe drop in blood pressure. Consequences may include dizziness, fainting, heart attack, stroke, or even death .

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For your safety, it's crucial to avoid using Cialis and poppers together. If you're considering using either substance, consult with a healthcare professional to understand the potential risks and ensure safe usage.
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